Authors born in 1959
- Rajeev Shukla Author, 1959
- Randall Terry Politician, 1959
- Randy DeBarge Singer, 1959
- Randy Travis Musician, 1959
- Raul de Molina Entertainer, 1959
- Rebecca De Mornay Actress, 1959
- Renee Fleming Opera Singer, 1959
- Renny Harlin Film Director, 1959
- Ricardo Semler Chairperson, 1959
- Richard Drummie Guitarist, 1959
- Richard Grossman Guitarist, 1959
- Richard LaGravenese Screenwriter, 1959
- Richard Roeper Columnist, 1959
- Richie Sambora Guitarist, 1959
- Rick Bragg Journalist, 1959
- Rigoberta Menchu Activist, 1959
- Robert Smith Musician, 1959
- Ryan Stiles Actor, 1959
- Ryne Sandberg Athlete, 1959
- Sade Adu Musician, 1959
- Said Aouita Athlete, 1959
- Said Seyam Minister, 1959
- Sam Raimi Actor, 1959
- Sandro Veronesi Novelist, 1959
- Sanjay Dutt Actor, 1959
- Sarah Ferguson Royalty, 1959
- Saul Perlmutter Scientist, 1959
- Scott Anderson Journalist, 1959
- Scott Garrett Politician, 1959
- Scott Hamilton Figure Skater, 1959
- Scott Thompson Actor, 1959
- Sean Bean Actor, 1959
- Sean Young Actress, 1959
- Sheena Easton Singer-Songwriter, 1959
- Sigmar Gabriel Politician, 1959
- Simon Cowell Producer, 1959
- Sivamani Musician, 1959
- Stephen Harper Politician, 1959
- Stephen Wolfram Physicist, 1959
- Steve McFadden Actor, 1959