I've heard that the two plants that make Ayahuasca (Banisteriopsis caapi and Psychotria viridis) in the Amazon, are increasingly difficult to find in the wild.
Ayahuasca, unlike mushrooms and all these other things is only as good as the person who made it. . . . The ayahuasca is a combinatory drug, and so it brings the human interaction and the lore of it into a much more central position.
Ayahuasca loves to take prideful people and rub their nose in it. I mean it can make you beg for mercy like nothing. You have to really approach it humbly.
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