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Cities are obvious metaphors for life. We call roads 'arteries' and so forth.
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A human being at rest runs on 90 watts. That's how much power you need just to lie down. And if you're a hunter-gatherer and you live in the Amazon, you'll need about 250 watts. That's how much energy it takes to run about and find food.
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Exciting cities stay exciting, and boring cities stay boring.
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Every fundamental law has exceptions. But you still need the law or else all you have is observations that don't make sense. And that's not science. That's just taking notes.
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Cities are just a physical manifestation of your interactions, our interactions, and the clustering and grouping of individuals.