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Future is not extrapolation of past
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Spreadsheets are fiction. Believing in what you're doing and what you're building is what's important.
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If you're going to re-invent healthcare you have to start from scratch.
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Imagine the world of mobile based on Nokia and Motorola if Apple had not been restarted by a missionary entrepreneur named Steve Jobs who cared more for his vision than being tactical and financial.
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Screw up often; but screw up ahead of everybody else, and than learn as much, and than use it to make subsequent investments.
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My willingness to fail gives me the ability to succeed.
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Letting the perfect be the enemy of the good is one of the reasons we have a coal-dependent infrastructure, with the resulting environmental impact that all of us can see. I suspect environmentalists, through their opposition of nuclear power, have caused more coal plants to be built than anybody. And those coal plants have emitted more radioactive material from the coal than any nuclear accident would have.
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Everybody else is afraid to fail. I do not really care because when I fail, I try something new.
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In my view, it’s irreverence, foolish confidence and naivety combined with persistence, open mindedness and a continual ability to learn that created Facebook, Google, Yahoo, eBay, Microsoft, Apple, Juniper, AOL, Sun Microsystems and others.
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How would you compete against yourself?
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The only way you multiply resources is with technology. To really affect poverty, energy, health, education, or anything else - there is no other way.
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The first rule of venture capitalism is hands-on experience. You have to get your hands dirty.
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The state of healthcare today is that we are busy in the practice of medicine vs. being in the science of medicine.
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Any problem is an opportunity. The bigger the problem, the bigger the opportunity.
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Seeking an acquisition from the start is more than just bad advice for an entrepreneur. For the entrepreneur it leads to short term tactical decisions rather than company-building decisions and in my view often reduces the probability of success.
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Oil replacements and then efficiencies in engines and housing and the way we build houses is a very interesting market.
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Startups allow technologists and scientists to take risks and change plans in a way that would be frowned upon in a big company. Having said that, big companies will play a key role in certain areas and in partnerships with little companies. Each has its strengths.
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You have to invent the future you want.