Authors born in 1821
- Alexander Gardner Photographer, 1821
- Ardant du Picq Military Personnel, 1821
- Arthur Cayley Mathematician, 1821
- Charles Baudelaire Poet, 1821
- Charles Tupper Minister, 1821
- Clara Barton Nurse, 1821
- Collis Potter Huntington Businessman, 1821
- Cyprian Norwid Poet, 1821
- Daniel Harvey Hill General Authority, 1821
- Eduard Heine Mathematician, 1821
- Elizabeth Blackwell Scientist, 1821
- Ernst Engel Economist, 1821
- Frank Leslie Engraver, 1821
- Frederick Locker-Lampson Poet, 1821
- Fyodor Dostoevsky Novelist, 1821
- George Bowen Author, 1821
- George Linnaeus Banks Journalist, 1821
- George McDougall Missionary, 1821
- George W. Sears Journalist, 1821
- George Whyte-Melville Novelist, 1821
- Hermann von Helmholtz Physician, 1821
- James Longstreet Military General , 1821
- Jay Cooke Financier, 1821
- John Abbott Lawyer, 1821
- Jules François Felix Fleury-Husson Writer, 1821
- Karol Mikuli Pianist, 1821
- Mary Baker Eddy Scientist, 1821
- Nathan Bedford Forrest Military Personnel, 1821
- Norman Macbeth Painter, 1821
- Octave Feuillet Novelist, 1821
- Pafnuty Chebyshev Scientist, 1821
- Thomas Mitchell Morris Golfer, 1821
- William Henry Vanderbilt Businessman, 1821