Authors born in 1981
- Sean Durkin Director, 1981
- Sean Hampton Actor, 1981
- Serena Williams Tennis Player, 1981
- Seth Gabel Actor, 1981
- Sheridan Smith Actress, 1981
- Sienna Miller Actress, 1981
- Simon Ammann Athlete, 1981
- Stephanie Perkins Author, 1981
- Summer Glau Actress, 1981
- Susan Kelechi Watson Actress, 1981
- Susanna Phillips Singer, 1981
- Sébastien Lefebvre Musician, 1981
- T. J. Miller Actor, 1981
- T. V. Carpio Singer, 1981
- Tabrett Bethell Actress, 1981
- Tahar Rahim Actor, 1981
- Taufik Hidayat Badminton Player, 1981
- Taylor Kinney Art Model, 1981
- Taylor Kitsch Actor, 1981
- Tom Meighan Singer, 1981
- Troy Polamalu Athlete, 1981
- Tulsi Gabbard Politician, 1981
- Tyler Winklevoss Rower, 1981
- Una Healy Singer-Songwriter, 1981
- Uzo Aduba Actress, 1981
- Valzhyna Mort Poet, 1981
- Vanessa Bayer Actress, 1981
- Vanessa Ray Actress, 1981
- Victoria Legrand Singer, 1981
- Walter Wright Boxer, 1981
- Wendy Starland Singer-Songwriter, 1981
- Wes Welker American Football Player, 1981
- Will Poole American Football Player, 1981
- Willie Green Basketball Player, 1981
- Willie Taylor Singer, 1981
- Xabi Alonso Football Player, 1981
- Yo Gotti Rapper, 1981
- Young Buck Musician, 1981
- Yuvraj Singh Cricketer, 1981
- Zach Cregger Screenwriter, 1981